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Once Nrf2 is activated, the storage of iron would increase, OS would be inhibited, and the occurrence of ferroptosis could be directly blocked

281 Melatonin inhibits the stress effect of ER through the melatonin receptors type 1B (MT2)/cAMP/protein kinase A (PKA)/inositol-requiring enzyme 1 (IRE1) pathway, reducing hepatic ferroptosis in MAFLD

Phase II Liver Detoxification Pathway Phase II liver detoxification neutralizes the byproducts of Phase I liver detoxification and other remaining toxins

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PC is the fundamental backbone of liposome technology, creating a tight, structured bilayer that prevents the glutathione from oxidizing prematurely