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PLX4720 suppressed cell viability in several BRAF V600E altered cell lines and patient-derived orthotopic xenografts (PDoX) from DBTRG-05MG and AM38, with PDoX recapitulating the in vitro sensitivity to BRAF inhibitors ( Table 2 ) including PLX4720 monotherapy ( Table 1 A list of patient-derived cell lines representing various BRAF V600E -mutated tumor subtypes