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Although effective as a treatment for acute aldehyde toxicity associated with the use of these agents, the hydrophilicity of MESNA prevents it from readily entering cells, limiting its usefulness for the treatment of DR (47)

Lipodystrophy: Syndrome of severe insulin resistance

38 (2), e23422

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Castro-Portuguez R, Sutphin GL (2020) Kynurenine pathway, NAD+ synthesis, and mitochondrial function: Targeting tryptophan metabolism to promote longevity and healthspan