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This reaction results in the production of formaldehyde and demethylated histones, which contribute to dynamic chromatin remodeling and gene expression regulation 91

In depression, while direct evidence linking NF-B and GPX4 remains limited, it has been established that both NF-B activation and GPX4 suppression contribute to brain injury, including neuronal loss, microglial overactivation, and reduced adult hippocampal neurogenesis (AHN) (Li et al., 2021

Storkebaum E, Carmeliet P (2004) VEGF: a critical player in neurodegeneration

10.1056/NEJMoa003417 158 VeseliB

Integration of target predictions from TargetScan, miRWalk, and miRDB identified nine potential miRNAs that target GGCT (Fig