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Randomization was stratified by multiple baseline variables including KPS, histologic subtype (epithelial, mixed, sarcomatoid, other), and gender

Subsequently, centrifuge at 4C and 14000 g for 5 min, and collect the supernatant as the membrane protein solution.The isolated membrane protein was used for western blot analysis with the H+ATPase antibody (Agrisera, AS07260)