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Moreover, the simulations confirmed that the Cagri P37 had weaker interactions with the ECDs leading to greater uncoupling of the peptide C-terminus from the ECDs (Supplementary Movie 1, Supplementary Tables 4, 5), and parallel increases in the dynamics of the peptide as it engaged with the CTR TM bundle, including F23

Compared with the results of prototype BPC157 in rats, the pharmacokinetic parameters of [ 3 H]BPC157 evaluated based on total radioactivity changed markedly, indicating the significant metabolism and decomposition process of BPC157 in vivo

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