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Nature 527 , 9599 (2015)

The body's natural antioxidant defenses, including endogenous glutathione, become rapidly depleted as they try to neutralize the constant influx of inflammatory damage

however, the accumulated excess intracellular cystine induces disulfide stress, leading to the overproduction of ROS and gradually promoting ferroptosis [16]

In man, colonic or rectal instillation of bile acid solution stimulates propulsive motility (171, 172)