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This is not proof of clinical harm at therapeutic doses, but it provides a plausible mechanistic basis for concern

Protective role of vitamin D receptor against mitochondrial calcium overload from PM2.5-induced injury in renal tubular cells

Tjiattas L, Ortiz DO, Dhivant S, Mitton K, Rogers E, Shea TB (2004) Folate deficiency and homocysteine induce toxicity in cultured dorsal root ganglion neurons via cytosolic calcium accumulation

It most commonly happens in the legs

Collectively, these biochemical properties position forskolin as a valuable molecule for developing treatments aimed at reducing IOP, protecting against oxidative and inflammatory damage, and preserving neuronal health in various eye diseases (Figure 4)