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doi: 10.1038/s41416-021-01383-0, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 30.Yuan S, Mason AM, Carter P, Burgess S, Larsson SC

The addition of GIPR activity was the key pharmacological innovation of tirzepatide, enabling greater weight loss than pure GLP-1 agonism

This formulation aligns with repeated-access vial management, maintaining an observed multi-use handling window of 28 days for documented research-use protocols