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The evidence on DLT still appears weak, so more verifications are necessary

The upregulation of glucose-6-phosphate isomerase facilitates a greater metabolic flow into the pentose phosphate pathway, thereby supporting antioxidant responses ( + and NADH levels, prompting bacteria to downregulate certain key enzymes to prevent NAD + depletion, thus maintaining the balance of energy metabolism and cell survival

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Although no significant differences were initially observed between the groups after 3 months, the use of the gel resulted in an 85% disease resolution rate, compared with a 70% resolution rate without adjunctive application of the gel (Reference Iorio-Siciliano, Marasca and Mauriello104)