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Detachment of cytochrome c from cardiolipin might also be triggered by increased cytosolic calcium, which weakens the electrostatic interaction between cytochrome c and cardiolipin and further generates ROS via MPT

The International Agency for Research on Cancer evaluated carbon tetrachloride in 1978 (IARC, 1979), and re-evaluated it in 1987 (IARC, 1987) and 1998 (IARC, in press)

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Contamination of primary tissue could possibly be carried over to culture preparation