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Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses

Glucocorticoids remain the guideline-recommended standard of care for selected patients

for instance, CYP1A1 and CYP1A2 induced by TCDD were shown to be protective in Cyp1a1/1a2 double-knockout mice, revealing the complexity of the AhR signaling pathway ( The molecular basis for this functional duality remains to be fully elucidated