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Graphical Abstract Similar content being viewed by others Introduction In less than two decades since Yamanaka and colleagues first published a protocol to reprogram somatic cells back to a pluripotent state using key transcription factors such as Oct4, Sox2, Klf4, and c-Myc, the field of human induced pluripotent stem cells (hiPSCs) has undergone remarkable advancements [1, 2]

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