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These genetic and environmental factors interact to trigger persistent epithelial injury and dysregulated repair, central to the fibrotic remodeling seen in IPF

454 Moreover, centrally mediated factors, such as cognitive processes (e.g., attention, distraction, catastrophizing), contextual beliefs about pain, and emotional states (e.g., depression, anxiety), significantly influence the pain experience

Collectively, these findings highlight the potential of amino acids such as arginine, proline, glutamate, methionine, cysteine, glutamine, and BCAAs as novel biomarkers for IPF diagnosis, disease staging, and progression monitoring

Chen M, Tian H, Huang G, Fang T, Lin X, Shan J, et al