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A microdialysis method for the recovery of IL-1beta, IL-6 and nerve growth factor from human brain in vivo

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The results at the short-term time point (1 h) suggested that uric acid may induce oxidative stress, leading to protein carbonylation in VSMCs and a high reactivity of uric acid with cellular proteins indicating that it may rapidly cause oxidative modifications

This promoted the translocation of Bcl-2 to the outer mitochondrial membrane, where it interacted with voltage-dependent anion channel 1, inhibiting mitochondrial permeability transition pore (mPTP) opening

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