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MOTS-c is discussed in metabolic and mitochondrial research

"It occurs in people whose B12 deficiency is caused by pernicious anemia," explains vitamin B12 expert and researcher Ralph Green, MD, PhD, a Distinguished Professor at the UC Davis School of Medicine

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Second, and more critically, the expansion of water as it freezes can create immense pressure inside the vial, potentially causing micro-fractures in the glass or compromising the seal of the rubber stopper