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49 The second one is safety, which is a critical issue

Regulation of 25-hydroxyvitamin D3 1alpha-hydroxylase gene expression by parathyroid hormone and 1,25-dihydroxyvitamin D3

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Histological analysis confirmed that miR-ADSCs enhanced eNOS and VEGFa expression in penile tissues, reduced apoptosis, and preserved smooth muscle integrity, suggesting that miR-423-5p inhibition in ADSCs enhances their therapeutic efficacy for DMED by simultaneously upregulating the eNOS and VEGFa pathways [102]