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Darley-Usmar VM, Hogg N, OLeary VJ et al (1992) The simultaneous generation of superoxide and nitric oxide can initiate lipid peroxidation in human low density lipoprotein

Research demonstrates that carnosine can inhibit the secretion of tumor necrosis factor- (TNF-) and interleukin-6 (IL-6), among other inflammatory mediators, thereby reducing inflammation (21-24)

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Thus, CRISPR/Cas9-based gene therapy has reached the clinical trial stage for many monogenic diseases such as sickle cell anemia [7], -thalassemia [7], hereditary tyrosinemia type I [8] and is being applied in advanced preclinical testing stages of Duchenne muscular dystrophy (DMD), hemoglobinopathies, and hereditary tyrosinemia type I

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