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10.1016/j.lfs.2019.116633 71 KudryavtsevaA

10.1038/s41598-018-35011-4 43 MehrkensA.MullerA

In contrast, active targeting relies on the active recognition between the molecules on the NPs surface and the specific molecules or proteins in the disease microenvironment, which is also referred to as ligand-receptor specific binding

This imine carbon is susceptible to further nucleophilic addition by a second amine, forming an irreversible cross-link composed of a methylene bridge ( Figure 1A