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Studies suggest that the human GI tract harbors more than 800 different individual bacterial species (Turnbaugh et al., 2010) with proportional representation, genus level distribution, and viable count of colony-forming units (CFUs) varying widely from the oral cavity to the rectum (Hayashi et al., 2005

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[DOI] [PubMed] [Google Scholar] 43.Nexo E, Hoffmann-Lucke E

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Its weighing whether the substance can be consistently characterized, whether there are safety concerns (including impurities and immunogenicity), and whether the proposed uses have any credible evidence behind them

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