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Since the middle of the 20th century, the identification of these bioactive compounds, ranging from polyketides (PKs) to nonribosomal peptides (NRPs) and their hybrids, has been predominantly achieved through activity-based testing of cultivatable microorganisms, particularly Actinomycetes soil bacteria (Katz and Baltz, 2016)

In such autophagy-dependent cancers, agents such as hydroxychloroquine can sensitize tumor cells to chemotherapy and suppress cancer stemness by disrupting autophagic flux