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Patients in remission at D2 ( n = 11, = 2.9 0.25) presented a smaller number of previous unsuccessful antidepressant treatments than patients that did not achieve remission ( n = 17, = 4.5 0.43) (MannWhitney: U = 33, p = 0.003)

In parallel, TB-500 appeared to increase expression of angiogenesis-linked factors, including VEGFA, angiopoietin-2 (Ang2), and the Tie2 receptor

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