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Notably, the remission phase of MDE in bipolar disorder patients is characterized by a heightened prevalence of CD4 + CD25 + FOXP3 + CD152+ cells and a reduction in effector T cells [149]

NNMT is an enzyme that transfers a methyl group from S-adenosyl-L-methionine to nicotinamide, producing 1-methylnicotinamide and S-adenosyl-L-homocysteine