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Resistance to chemotherapy and radiotherapy is both intrinsic and acquired: the blood-brain barrier makes delivery of chemotherapeutic drugs to neoplastic cells difficult, and GBM itself is molecularly heterogeneous and often features robust DNA repair mechanisms such as enhanced methylated-DNA-protein-cysteine methyltransferase (MGMT) activity ( This review examines the metabolic landscape of GBM, with a focus on the widespread reprogramming of energy pathways that enables tumor cells to adapt and thrive in harsh microenvironments

10.1016/j.cbi.2005.12.009 141 WadeyA

1), supporting the essential role of Bim in the mitochondria, and not other apoptotic proteins, in the context of HIV

Reduced and oxidised glutathione should not be treated as identical analytical substances, even though cells continually interconvert them

Chen F, Du M, Blumberg JB, Ho Chui KK, Ruan M, Rogers G, et al