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Description

The gene encoding the human isoform of OCTN2 has been annotated and cloned in 1998, in parallel to the murine one (Tamai et al., 1998, 2000

A recent review has further elucidated the dynamic interplay between mitophagy and ferroptosis in IDD, primarily mediated by ROS as a key mediator and involving pathways such as AMPK/mTOR and Nrf2/Kelch-like ECH-associated protein 1(86)