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Upon recruitment, the membrane adhesion proteins such as intercellular adhesion molecule-1 on endothelial cells are up-regulated, and the proteins including integrin 2, macrophage-1 antigen, and lymphocyte function-associated antigen 1 are overexpressed on the neutrophil membrane, together facilitating the transmigration

499 GPX4 is significantly decreased in the hearts of patients with diabetes and hyperglycemia, indicating that GPX4 may play an antioxidant role in diabetic cardiomyopathy

It modulates expression of more than 4,000 human genes, including 84 cancer-suppressing genes

Ethics declarations Financial Support The preparation of this manuscript was supported by funding from Health@InnoHK Initiative Fund of the Hong Kong Special Administrative Region Government (ITC RC/IHK/4/7) and Vincent and Lily Woo Foundation

In CFS patients, Hornig and colleagues demonstrated a considerable increase in pro-inflammatory cytokine levels in the cerebrospinal fluid, with immune activation and a shift towards T helper type-2 pattern associated with autoimmunity (Hornig et al