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Studies have shown that mitochondrial therapeutics may have the potential to slow the progression of POAG by protecting against mitochondrial decline associated with age, genetic susceptibility, and other pathology
At the same time, VK reductase Ferroptosis Inhibitory Protein 1 (FSP1) inhibits ferroptosis by reducing VK to VKH2 and prevents lipid peroxidation by depleting NAD(P)H (Li et al., 2023)
The ACSL4 inhibitor rosiglitazone improves kidney function in DKD mice and reduces the lipid peroxidation product and iron content, and these effects are correlated with attenuated ferroptosis (23)
Ion channels in osteoarthritis: emerging roles and potential targets
