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At higher quantities, mild hypotension and a temporary decrease in concentration have been described in individual observations, likely related to the sedative profile of the compound

Further, MSCs from Igf1r flox/flox mice with Igf1r deleted by a Cre adenovirus in vitro , although recruited to the bone surface after implantation, were unable to differentiate into osteoblasts

The method accuracy was determined by calculating percentage (%) of recovery and relative standard deviations (RSD) was calculated for each concentration

Histopathological features containing vascular and parenchymal changes were graded categorically, according to the scheme of Rubbia-Brandt et al (2010)

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