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Description

Tomar MS, Kumar A, Srivastava C, et al

Polyamines: functions, metabolism, and role in human disease management

Given that NACA was able to counteract the effects of the ACOX1 gain-of-function mutation, antioxidant treatment was considered for patient#1 during a severe disease flare

This is supported by findings in bone marrow-derived macrophages, where treatment with RBCs to induce EP resulted in a marked increase in HO-1 expression (approximately 10-fold) (87)