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Aug 15 2010;82(4):361-8, 369

While, in westernized societies, acne is a nearly universal skin disease afflicting up to 95 percent of teens, in some populations eating more traditional diets, not even single cases could be found

An interesting experiment shows how, in the presence of insulin resistance, there is up-regulation of the insulin/IGF-1 hybrid receptor expression in both, muscle and fat [133, 156]

It also helps lower the risk of long-term diabetes-related complications

They provide strong proof that a compound has a direct biological effect on the target tissue, but they cannot tell us how that compound will behave when applied to human skin (where absorption, distribution, and metabolism add complexity)