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If neurological symptoms are present, injections may continue on alternate days until no further improvement, followed by maintenance injections every 2-3 months for life Oral B12 supplementation : High-dose oral cyanocobalamin (10002000 micrograms daily) may be effective for dietary deficiency without malabsorption

In fact, there is a metabolic reason that gastric bypass and, to some extent, duodenal switch patients experience B12 deficiency

doi:10.1055/s-0042-1758377

Freezing can cause the peptide to precipitate out of solution, forming particles that do not re-dissolve upon thawing

On the right, the diagram is labelled Ulcerative Colitis