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CIT, classified as a non-essential amino acid and a precursor to L-arginine, has been shown to facilitate the production of NO and promote vasodilation, consequently enhancing endothelial functionality and muscle perfusion (911)

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Moreover, Mn decreased REST expression in astrocytes, while overexpression of astrocytic REST exerted protection against Mn-induced neuronal cell toxicity by regulating inflammatory cytokines and glutamate transporter GLT-1/EAAT2 in astrocytes (Pajarillo et al., 2021)

Over the years, disulfide-containing compounds (-SS-) have been extensively explored in the development of GSH-sensitive drug delivery systems (DDSs) [52]

As a biomarker in clinical practice, it has been suggested as a proxy to evaluate neuroinflammation ( Although CNS IDDs might differ in several aspects, as previously mentioned, the extensive role performed by glial cells in neuroinflammation is a convergence point among them