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Nat Rev Endocrinol 3 , 396404 (2007)

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Results Accord origins and specifications Through the late 1980s and early 1990s, public health consensus on the negative health effects and addictiveness of smoking led to smoke-free policies and the broader social denormalisation of smoking.12 In response to these pressures, RJ Reynolds introduced its clean smoke heated tobacco product, Premier, in 1988.13 Although similar to a conventional cigarette, Premier heated tobacco, instead of burning (combusting) it, producing an aerosol for inhalation.14 15 Industry scientists hypothesised that such products presented a lower health risk to users: because tobacco was not combusted, smokers might beexposed to fewer respiratory irritants and carcinogens.1 Marketed as a smokeless, cleaner cigarette, Premier was widely rejected by consumers and pulled from shelves within 4 months of its release

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When Juul first hit the market in 2015, its vape liquid contained much higher levels of nicotine than e-cigs already on the market