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Trial SURPASS-1 (Lancet 2021) Population 478 adults with T2D, monotherapy vs placebo

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Les patients souffrant de maladies gastro-intestinales : la maladie de Crohn, la maladie cliaque ou une gastrite atrophique perturbent lassimilation

Alternatives include sterile water for injection (single-use, no preservative) or normal saline for injection (sterile saltwater solution)

How to take it: Tablets, swallow with water, after food Sublingual tablets, place under the tongue, let it dissolve Injection, given by a doctor or nurse, usually in muscle (intramuscular) Never self-inject without proper medical guidance When to take it: Morning is generally preferred Taking it with food helps reduce any mild nausea Try to take it at the same time every day for consistency Dosage guidelines (general reference): Mild deficiency, 500 to 1000 mcg orally per day Severe deficiency, 1000 to 1500 mcg via injection, daily or alternate days initially Maintenance dose, 1000 mcg monthly injection in many cases What Research Says: According to NIH clinical data, initial treatment for severe B12 deficiency often involves daily injections for 1-2 weeks, followed by weekly, then monthly doses