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Second, synergy with other agents (e.g., MI) is biologically plausible but clinically under-tested in factorial designs

Another strategy catalyzes glucose into gluconic acid and H 2 O 2 by exerting GOD-like or loaded GOD, which not only lowers the pH of the wound microenvironment to promote POD-like activity, but also replenishes the H 2 O 2 substrate [304,305,306,307,308,309]

Dot plots show the percentage of cells forming NETs in all dead neutrophils from the indicated group

This bidirectional interplay between systems contributes to a robust and layered antioxidant defense network