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In IL-10 (/) mice, AA mitigates colitis by inhibiting activation of the TLR4 pathway, reducing levels of Bax and Cleaved caspase-3, and suppressing intestinal epithelial cell apoptosis [123]

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Historical Background and Scientific Context Mitochondrial-derived peptides emerged as an important area of scientific research following the discovery that mitochondrial DNA encodes biologically active peptides capable of participating in intracellular signalling networks

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