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The gut microbial metabolite trimethylamine N-oxide aggravates GVHD by inducing M1 macrophage polarization in mice

Washington, DC: National Academy Press, ISBN 0-309-06997-1 Minson, D.J

While its direct free radical scavenging activity is modest compared to classical antioxidants, creatine nonetheless contributes to redox homeostasis by reducing reactive oxygen species (ROS) and preserving mitochondrial integrity

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That can cause foaming and potentially denature the peptides