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Description

As AC signalling pathway is the major transduction route mediating VIP effects, intracellular cAMP accumulation in PBMC was measured following stimulation with VIP or VPAC selective agonists (Table 2)

Patients may experience acneiform rash, xerosis (dry skin), pruritus, paronychia, hand-foot syndrome, and alopecia, with varying degrees of severity

10.1124/pr.110.003301 135 OhashiK.KawaiS.MurataK

Localized Treatment : Targeting the problem area directly, ICP minimizes systemic side effects and does not interfere with other ongoing treatments

Studies may also have used high doses of one agent, which may have resulted in a reduced uptake and/or distribution of other substances with important metabolic activity