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In colorectal cancer, although SREBP1 mRNA levels are not significantly elevated, activation of the AKT-mTOR pathway may increase the nuclear accumulation of SREBP1 proteins

Supplementation with vitamin E may also be of benefit in children with sickle cell anemia, as one study showed that six weeks of alpha-tocopherol supplementation improved several metrics of diseases severity in this population (Jaja 2005)