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Studies on the evaluation of the association between GPx1 and atherosclerosis variants in Japanese patients with type 2 diabetes, with four polymorphisms, reported that functional variants of the GPx1 gene are associated with increased mean intima-media (IMT) thickness of carotid arteries and cardiovascular risk and peripheral vascular disease in type 2 diabetics [63]

Gaucher disease glucocerebrosidase and alpha-synuclein form a bidirectional pathogenic loop in synucleinopathies

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In contrast, intracellular NOD-like receptors (NLRs), such as NOD1/NOD2, primarily sense bacterial peptidoglycan fragments (e.g., iE-DAP and MDP)

Finally, existing cccDNA may be degraded directly using genome editing with designer nucleases or indirectly through immune-mediated mechanisms, such as APOBEC enzymes [63]