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However, it is worth noting that the unwinding rate of Mer3-8A in the presence of RPA (upward yellow triangles) is slightly higher than in the absence of RPA (orange circles) at 14 pN since we have shown that 5 nM RPA can unwind the DNA duplex at 14 pN at higher velocity (grey diamonds), which likely contributes to the observed increase in rate

It doesnt bind significantly to GABA-A receptors, for example, making it mechanistically different from most pharmacological sleep aids

This substantial reserve explains why B12 deficiency takes years to develop even when dietary intake ceases

Superoxide dismutase mimetic GC4419 enhances the oxidation of pharmacological ascorbate and its anticancer effects in an H 2 O 2 -dependent manner

PubMed Gorouhi F