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493 Cell senescence can be accelerated when various organelles meet overloaded stress or proteotoxicity, such as misfolding of nuclear, ribosomal, peroxisomal, and mitochondrial proteins, 494,495,496,497 leading to aberrant protein aggregates that dampen the cross talk of organelles

A deeper, context-specific understanding of redox signaling, particularly the roles of redox-sensitive proteins, is critical for designing targeted therapies aimed at re-establishing redox balance

It plays a vital role in detoxification, immune function and helps combat free radicals, which can damage cells and contribute to aging

Discussion HNF4 is a context-dependent transcriptional regulator implicated in various cancers [9, 11, 15, 16, 18]

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