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Long-term effects of chronic GHS-R1a activation on cancer risk (GH and IGF-1 are growth factors), glucose metabolism (GH antagonizes insulin), and joint health are unknown

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In vitro glutathione deficiency alters vitamin D metabolism genes and VDR in mouse hepatocytes To rule out the non-specific effect of HFD conditions and other confounding variables in animals, we carried out in vitro experiments to determine the direct impact of glutathione deficiency status on VD metabolism genes in hepatocytes