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Even so, as with any product applied to the skin, the possible side effects are the ones common to anything applied to the skin: some people experience irritation, redness, itching or a contact reaction

In rheumatoid arthritis, for example, NET-immune cell interactions promote B cell proliferation and autoantibody production via B cell-activating factor, while synovial NETs provide citrullinated proteins that fuel anti-citrullinated protein antibody (ACPA) responses (89)

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The factors responsible for this reduced cholesterol in the plasma and meat may be similar

[29] Dyslipidemia Limited research suggests blood levels of cholesterol and lipids can be adversely affected when on the ketogenic diet