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17-estradiol plus P displayed anti-inflammatory effects by selectively reducing absent in melanoma 2 (AIM2) and NLR family CARD domain-containing protein 4 (NLRC4) inflammasomes in primary cortical astrocytes and microglia after ischemic stroke in rats (112)

Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a Tethering mechanism: a TWO-SITE INTERACTION MODEL FOR THE Nrf2-Keap1 COMPLEXA TWO-SITE INTERACTION MODEL FOR THE Nrf2-Keap1 COMPLEX

doi: 10.1136/bmj.303.6809.1026

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Furthermore, both adults and eggs of Schistosoma mansoni can induce M2-type polarization of M by peroxisome proliferator-activated receptor (PPAR) activation, which is beneficial to parasite survival (70) ( Figure 4 )