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Importantly, alcohol consumption exacerbates the problem.[ref] Alcohol Metabolism Genotype Report Access this content: An active subscription is required to access this content

When a strain of Streptomyces coelicolor with a disrupted relA gene was grown under nitrogen limiting conditions both ppGpp and secondary metabolite production were greatly reduced compared to a strain with an intact relA gene [9]

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Among these, maternal copy loss in the 15q11-q13 chromosomal region and maternal inheritance of UBE3A gene overexpression (such as in Dup15q syndrome) are both associated with the occurrence of autism (67, 68)