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This macrocyclic constraint restricts conformational flexibility, contributing to the extended biological activity duration observed versus native -MSH

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In practical terms: For someone whose sleep is suffering because of high stress, racing thoughts, or even poor recovery from physical exertion, DSIP may help smooth the transition into delta wave sleep and better restoration overnight

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[DOI] [PubMed] [Google Scholar] 43.Ettl T, Viale-Bouroncle S, Hautmann MG, Gosau M, Kolbl O, Reichert TE, et al