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His acting prowess, his star power to guarantee a box office hit, his engaging off-screen romances, and his irresistible looks earned him the People 's Sexiest Man Alive title twice

The clinical and experimental characteristics of the IBD patients, including their smoking history, are summarized in Supplementary Table 3

Cigarettes deliver just enough nicotine to stimulate dopamine release and reinforce pleasure without fully satisfying

If unable to find satisfying alternatives, adults who smoke and transition to reduced harm products may return to smoking or purchase products illicitly if their preferred products are removed from the regulated market

This is especially pertinent for tobacco use, given many begin smoking as teenagers