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One in five adults 1.25 billion users worldwide consume various tobacco products such as cigarettes, heated tobacco products, water pipes, smokeless tobacco products, or cigars

Decades of research have thoroughly documented the health problems that result from inhaling tobacco smoke more than a dozen different types of cancer, heart disease, stroke, emphysema and other respiratory diseases, among others

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While this study demonstrates strong associations between CEdG levels and chromatin alterations, it does not establish temporal precedence or causality, which will require longitudinal and functional investigations