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Description

The degeneration of neurons in the ventral tegmental area, accompanied by reduced dopamine release and impaired connectivity in target regions, is recognized as a key feature of the early stages of AD, preceding even the formation of A plaques

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To accelerate clinical translation, clinically mature imaging techniques (e.g., MRI, CT) and FDA-approved materials (e.g., PEG) should be prioritized to exploit nanomedicines